THE ASSOCIATION BETWEEN HEMOGLOBIN A1C, FASTING GLUCOSE LEVEL AND LIVER FUNCTION TEST IN ADULTS UNDIAGNOSED WITH DIABETES-BASED ON KOREA NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY 2017

Back to Page Authors: Sat Byul Park

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Keywords: diabetes, HbA1c, GOT, GPT, liver function

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Abstract: Background: Glutamic oxalacetic transaminase (GOT) or glutamic pyruvate transaminase (GPT) has been used as a biomarker to check the abnormality of liver function. This study has been investigated for the relationship between serum glucose level markers and liver function and also for superior correlation reflects the liver function between Hemoglobin A1c (HbA1c) and fasting glucose level. Method: The Korea National Health and Nutrition Examination Survey in 2017 was utilized. 3575 adults were selected for undiagnosed diabetes, and divided by glucose level into 3 groups to find relationship with liver function by Analysis of Covariance (ANCOVA). Results: age, gender, weight, smoking, alcohol drinking and physical activity are adjusted. Increases in HbA1c was correlated with GPT (p=0.000), but not GOT (p=0.077). Fasting glucose level change was also associated with GPT (p=0.000), but not GOT (0.114). Conclusion: This study shows the linear association between HbA1c, fasting glucose level and liver function. It also shows that glucose level change is more correlative with GPT than GOT.

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